This is particularly challenging because chemokine receptors

As for the former, she didn’t get on any base. She reached home plate. Bolger led off the bottom of the first with her second homer of the season clearing the center field fence. The intricate coordination of leukocyte trafficking (migration to the right tissues at the right times) is controlled, to a large extent, by the specific interactions between the chemokines and their receptors. For this reason, we have a major research effort towards understanding the structural basis of these specific interactions. This is particularly challenging because chemokine receptors are G protein coupled receptors (integral membrane proteins) making them difficult to isolate or characterize in detail.

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