Antidepressants Can Cause Long
Shortly after Prozac became the best selling drug in the world in the early 1990s, I proposed that there was little or Canada Goose Coats On Sale no evidence for efficacy, but considerable evidence that the drug would worsen depression and cause severe behavioral abnormalities. canada goose coats on sale I attributed much of the problem to “compensatory changes” in neurotransmitters as the brain resists the drug effect. Since then, in a series of books and articles, I’ve documented antidepressant induced clinical worsening and some of its underlying physical Canada Goose Online causes. Now the idea has gained ground in the broader research community and canada goose deals has recently been named “tardive dysphoria.”
It has been apparent for many https://www.thecanadagooseoutlet.com years that chronic exposure to SSRI antidepressants frequently makes people feel apathetic or less engaged in their lives, and ultimately more depressed. In my clinical experience, this is a frequent reason that family members encourage patients to seek help in reducing or stopping their medication. SSRI induced apathy occurs in adults and includes cognitive and frontal lobe function losses. (See Barnhart et al., 2004; Deakin et al., 2004; Hoehn Saric et al., 1990). It has also Canada Goose online been identified in children. Adults with dementia are canada goose particularly Canada Goose sale susceptible to antidepressant induced apathy.
A recent scientific study by El Mallakh and his colleagues reviewed the antidepressant literature and concluded that any initial improvements are often followed by treatment resistance and worsening depression. They compare this problem to tardive dyskinesia, caused by antipsychotic drugs, and call it tardive dysphoria, “an active process in which a depressive picture is caused by continued administration of the antidepressant.” Based on rat studies, they hypothesize that “dendrite arborization” an increased branching growth of nerve cells caused by chronic antidepressant exposure, may be the cause.
In canada goose black friday sale a meta analysis of 46 studies, Andrews et al. (2011) found the relapse rate for antidepressant treated patients (44.6 percent) was much Canada Goose Outlet higher than for placebo treated patients (24.7 percent). Andrews also found that the more potent antidepressants www.thecanadagooseoutlet.com caused an increased canada goose store risk of relapse on drug Canada Goose Parka discontinuation. A 2010 Minnesota evaluation of patient care in the state found that only 4.5 percent of more than 20,000 patients were in remission at 12 months, indicating that they had become chronically afflicted with depression during and probably as a result of their treatment.
Andrews et al. (2011), like El Mallakh et al. (2011), stress what I had first described as compensatory mechanisms. SSRI antidepressants block the removal of serotonin from the synapses between neurons, in effect canada goose clearance sale trying to flood these canada goose coats synapses with serotonin. Many buy canada goose jacket studies confirm that the brain attempts to compensate for the impact of the SSRIs by reducing the brain’s capacity to respond to serotonin. This leads to a loss of serotonin receptors that can reach 60 percent. Blockade of serotonin reuptake causes a potentially harmful adaptive response in buy canada goose jacket cheap the form of a persistent hypertrophy of the reuptake mechanism. Additional studies show persistent biochemical changes in the brain following exposure to SSRI antidepressants.
In addition, I have been describing direct toxic effects on the brain that can account for the emotional deterioration of these patients. Prolonged SSRI antidepressant use can produce abnormal cell growth in the Canada Goose Jackets rat brain (neurogenesis) and canada goose clearance decreased thalamic volumes in children (tissue shrinkage from cell death). Thus far, most researchers have not yet begun to take into account or to face these more gross threats to the integrity of the patient’s brain after prolonged exposure to antidepressants. Meanwhile, drug induced changes in brain cell structure and number, when found as a result of taking illegal drugs, are always touted as a reason not to take these drugs.
Antidepressants canadian goose jacket are the second most prescribed group of drugs in America. Yet evidence continues to converge on the dangerousness of antidepressant drugs. Given the difficulty showing any effectiveness even in the short term, the use of these drugs becomes more and more problematic. On top of that, the antidepressants produce serious withdrawal reactions, making it difficult and at times life threatening to withdraw from them, even with the recommended clinical supervision and slow taper. Psychiatry has canada goose replica always been slow to respond to scientific evidence that its treatments are harmful. Often, as in this case, psychiatry flouts science. The public will have to develop its own resistance to taking antidepressant drugs.
Peter R. is a Harvard trained psychiatrist and former full time consultant with NIMH who is in private practice in Ithaca, New York. Dr. His most recent book is Medication Madness, the Role of Psychiatric Drugs in Cases of Violence, Suicide and Crime. On April 13 15, 2012 in Syracuse, New York, the annual conference of Dr. Breggin’s 501c3 nonprofit international organization, The Center for the Study of Empathic Therapy, will present a panel of lawyers, experts, survivors and families concerning antidepressant induced violence and crime cheap Canada Goose.