If you find a zipper, simply pull it open

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The ansamycin antibiotics, such as geldanamycin and herbimycin A are known to inhibit Hsp90 function and analog compounds, such as 17 allylamino 17 desmethoxygeldanamycin (17 AAG), have successfully progressed to stage II patient clinical trials. In preclinical human xenograft models, we and others, have shown that 17 AAG possesses potent anti tumour activity. However, recently we discovered that in the bone microenvironment, 17 AAG promotes tumour growth through its ability to stimulate bone degradation.

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